Oxyrase for Super Resolution Microscopy

By Lisa Stewart

July 18, 2017

Oxyrase for Super Resolution Microscopy


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Image courtesy of: Kees Jalink/ Leila Nahidiazar, NKI Amsterdam

Recently we noticed an increased trend regarding OxyFluor inquiries.  What is stimulating this interest?  Approximately 40 citations for Oxyrase and fluorescence and 10 citations for OxyFluor and fluorescence have been published to date in 2016.

Interested in multi-color super resolution microscopy?  Here's one of our favorites:  Nahidiazar et al., PLoS ONE 11(7): e0158884

OxyFluor™ was formulated to meet the needs of the microscopist using fluorescent dyes.

Intense light used to stimulate fluorescence in some dyes also produces oxygen free radicals.  Under some circumstances, these oxygen free radicals result in photo bleaching which reduces intensity and duration of fluorescence.  Photo bleaching can significantly impact the quality of observation as well as the time of observation. Furthermore, oxygen free radicals interact with the biological materials under study and cause change. These changes may interfere with the biological function being studied.

The Oxyrase® Enzyme System in OxyFluor™ removes dissolved oxygen effectively and efficiently. This significantly reduces or eliminates the formation of oxygen free radicals under conditions employed for fluorescent microscopy and results in brighter cell images. OxyFluor™ provides a protective effect for the biological material being studied and is an excellent solution for live cell imaging and cell culture applications.

Working with T-cells?  See Nordenfelt et al., Nat Commun. 2016; 7: 13119.  PMCID: PMC5062559

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